Join date: May 15, 2022


Horsecore Linda Mini 3 [Updated] 2022




. . .Relationship between genotype and outcome of TNF-alpha inhibition in rheumatoid arthritis: a prospective multicenter study. To investigate whether the clinical response to anti-tumor necrosis factor-alpha (TNF-alpha) therapy can be predicted by analysis of TNF-alpha promoter polymorphisms. This was a multicenter study of 245 rheumatoid arthritis patients. The patients received adalimumab treatment and were followed prospectively for 6 months. The patients were divided into 2 groups according to the presence or absence of HLA-DRB1*0401-DQB1*0302. Treatment response was defined as ≥20% reduction in the Disease Activity Score. The 6-month treatment response rates were 55.6% in the HLA-DRB1*0401-DQB1*0302 (+) group and 40.9% in the HLA-DRB1*0401-DQB1*0302 (-) group (P = 0.003). The presence of HLA-DRB1*0401-DQB1*0302 was associated with significantly better treatment response in patients with moderate to high disease activity at baseline and in patients receiving adalimumab monotherapy. The presence of HLA-DRB1*0401-DQB1*0302 was significantly associated with better response at 6 months regardless of whether the patients received adalimumab monotherapy or in combination with methotrexate. HLA-DRB1*0401-DQB1*0302 predicts a good treatment response in patients treated with TNF-alpha inhibitors.Oncogenic transformation and oncogenes. This is a review of events involved in cellular transformation. Both genetic and non-genetic mechanisms are included and we focus on the well-studied transforming DNA and oncogene systems, which are responsible for transformation. Transformation is a multi-step process involving many different components, including cell receptors and signalling pathways, which when altered result in aberrant cell growth and, potentially, cancer. Transformation is a result of both gain of function and loss of function alterations. We describe the oncogenes implicated in several malignancies and discuss how they function in human cancer, focusing in particular on the common occurrence of mutations of these genes. This review is intended to be of general interest to the non-specialist but we hope it will also be informative to the specialist.Chiral




Horsecore Linda Mini 3 [Updated] 2022

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